The driver of one of the vehicles, a 51 year old from Mahanoy City, died at the scene. Robin Capone, 52, of Mahanoy City, was the passenger in the vehicle and died at the hospital.
Morea Road was closed for a few hours while the State Police and Coroner's office investigated the crash.
Two other people were also hurt in the crash but the extent of their injuries has not be released.