Around 3pm, emergency personnel were called to the area of Deadman's curve on Route 61 southbound on the Frackville Grade between Frackville and St. Clair.
Altamont and Englewood Fire Companies were called to the scene.
Early reports are the accident involves a vehicle and tractor trailer.
Currently the driving lane is closed, avoid the area if possible.
UPDATE: Units cleared the scene just before 4:00pm