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Around 8:00pm, Tuesday evening, fire crews were called to a house fire at 72 Main Street, Klingerstown, in Upper Mahantango Township.
When crews arrived they found the home fully engulfed in flames.
Officials say that one person died in the fire, but no name has been provided at this time.
The fire was brought under control within an hour.
A Pennsylvania State Police Fire Marshal is investigating a cause of the fire.
Emergency personnel from Schuylkill, Northumberland, and Dauphin were called to the scene.