Police say a vehicle driven by Peter Kulik III, 33, of Kulpmont crashed into the rear of a tractor trailer driven by David Tucker, 34, of Edwardsville.
Kulik's vehicle wedged underneath the tractor trailer as it traveled and eventually stopped on the side of the road.
Kulik's vehicle was reported to be severely damaged but he was able to climb out of the crushed vehicle.
Tucker was uninjured in the crash but Kulik was taken to the hospital via Tremont Ambulance for serious injuries. He was not reported to have been wearing a seat belt.
The tractor trailer was not severely damaged but was towed from the scene.
Assisting at the scene was the Tremont Fire Company.