Just before 3:30pm, Monday, emergency personnel were called to 1140 Centre Turnpike (Route 61 Northbound), Orwigsburg for a motor vehicle accident.
No other details about the crash are available at this time but Northbound lanes have been closed at the Red Church.
A helicopter has been called to transport one of the victims.
UPDATE (3:35pm): A county coroner has been called to the scene.
More information when it is available.