Around 12:45pm, Wednesday, emergency personnel were dispatched to 924 near Frackville in the area of the "rock cut" for a 2 car crash with entrapment.
As of 12:50pm, the highway was closed in the area.
A Life Flight helicopter and Medivac Helicopter has been called as well. Shenandoah Fire has been called to handle the landing zones.
A Deputy Coroner has also been called to the scene.
More information as it comes available.