According to the Pennsylvania State Police at Frackville, the crash occurred just after 6:00am in the northbound lanes of Interstate 81 near mile marker 139 in Kline Township.
Police say two people were seriously injured when a 2015 Nissan Versa entered the median near mile marker 139 and rolled several times.
The Nissan came to a final rest on it's side in the median.
Both the driver and passenger, who were not identified, were extricated.
State Police are still investigating the crash.
Fire departments from McAdoo and Hazle Township assisted at the scene of the crash.
Photo Courtesy of the McAdoo Fire Department